In summary, among an older community-based cohort with a high prevalence of both OSA and insomnia symptoms, only insomnia with comorbid OSA (COMISA) or insomnia with short sleep duration on actigraphy appeared to associate with subclinical myocardial injury as expressed by cTnT, suggesting that these phenotypes may be of special relevance to sleep-related susceptibility to CVD. This evidence concerns the gene TNNT2 and insomnia.