Previous support for the V329M variant as benign comes primarily from the observation that methionine is the corresponding residue in Danio rerio myocilin, but the mutation has also been documented among glaucoma patients (Fingert et al., 1999; Liu et al., 2012; Shimizu et al., 2000; Svidnicki et al., 2018), including one diagnosed with juvenile OAG (Svidnicki et al., 2018). The gene discussed is MYOC; the disease is glaucoma.