MYOC and glaucoma: However, over the course of the last 20 years, some myocilin mutations that once were only found in glaucoma patients emerged from large-scale genome-sequencing projects, such as those collated in the Genome Aggregation Database (gnomAD, https://gnomad.broadinstitute.org/) (Karczewski et al., 2020), raising questions about the likelihood of their pathogenicity.