IL4 and pancreatic neoplasm: Hierarchical cluster analysis of the top 50 upregulated and top 50 downregulated genes in OCM pancreatic tumors identified four major biological processes that were altered in the tumors (Fig. 5B): (1) matrix metalloproteinases; (2) IL-4/IL-13 signaling; (3) early pancreatic precursors; and (4) digestion and absorption.