MYOC and open-angle glaucoma: For example, experimental studies conducted by Jain et al. showed that clustered regularly interspaced short palindromic repeats (CRISPR)-mediated genome editing of myocilin (MYOC)-dominant gain-of-function mutations effectively lowered IOP and hindered glaucomatous damage by inducing the loss of function of mutant MYOC in a mouse model of MYOC-associated POAG [126].