TARDBP and amyotrophic lateral sclerosis: Indeed, TDP-25 (prion-like TDP-43 fragment) mislocalizes to the cytoplasm forming aggregates in myoblasts (although to a lower extent when compared to MNs) and impairs autophagy [74], and pTDP43 inclusions were observed in ALS patient muscles [74,79] especially in axial skeletal muscles [79,80].