Semaphorin3A (SEMA3A) is an axonal guidance protein that acts as an axon repellent, preventing axonal regeneration by binding to its co-receptor, neuropilin1 (NRP1), and increased production of the protein is observed in the skeletal muscles of ALS animal models [125,126], NMJs of fast-fatigable muscle fibers and terminal Schwann cells [127], and the motor cortex of ALS patients [128]. The gene discussed is SEMA3A; the disease is amyotrophic lateral sclerosis.