Skeletal muscle-secreted C1q/TNF-related protein 3 (CTRP3) contributes to neuronal physiology by regulating neuronal protein synthesis, axonal outgrowth and protein synthesis rate in an mTOR dependent manner, and CTRP3 levels were reduced in the muscle secretome, serum and muscle tissues of a spinal muscular atrophy (SMA) animal model [123]. Here, C1QTNF3 is linked to spinal muscular atrophy.