Other examples of muscle secreted factors important for NMJ stabilization and dysregulated in ALS animal models and patients include: Insulin Like Growth Factor-1 (IGF-1) [137,138,139,140] or Glial-Cell-Line-Derived Neurotrophic Factor (GDNF) [141,142,143,144,145], Irisin [146] and Brain-Derived Neurotrophic Factor (BDNF) [138,147]. This evidence concerns the gene BDNF and amyotrophic lateral sclerosis.