Impairment in proteostasis may be due in part to mutations in ALS-associated proteins including SOD1, p62, valosin-containing protein (VCP), ubiquilin-2 (UBQLN2), optineurin (OPTN), and TANK-binding kinase 1 (TBK1) [82,83]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.