However, the frequency of CD14+CD16++ non-classical monocytes is increased in RA patients compared to healthy controls (7.595% ± 2.606, n = 19), the difference statistically significant in DMARD responders (10.93% ± 4.978, n = 24, p = 0.017) (Figure 3C). The gene discussed is CD14; the disease is rheumatoid arthritis.