The frequency of CD14++CD16− classical monocytes is significantly lower in RA responders (21.37% ± 9.68, n = 24) and DMARD non-responders (22.09% ± 15.03, n = 32), compared to healthy controls (45.03% ± 20.33, n = 19, p < 0.001) (Figure 3B). Here, CD14 is linked to rheumatoid arthritis.