INS and lipodystrophy: A Worldwide Injection Technique Questionnaire Study including 13,289 participants with DM found that people with lipodystrophy had higher HbA1C values, on average by 0.55%, a higher number of hypoglycemic events, greater glycemic variability, greater risk of ketoacidosis, and a greater total amount of insulin dose administered, on average 10 IU [28].