Ramacciotti et al. has shown that a combination of serum-soluble P-selectin level and Wells score could establish (cut point ≥ 90 ng/mL + Wells ≥ 2) (specificity: 96%; positive predictive value: 100%) and refute DVT diagnosis (cut point ≤ 60 ng/mL + Wells < 2) (sensitivity: 99%; specificity: 33%; negative predictive value: 96%) [24]. Here, SELP is linked to deep vein thrombosis.