Two of these SNPs map onto coding genes: rs780943500 maps to the transcriptional activator ELF4 with the role in innate immunity and natural killer cell function, and rs29282 maps to the FMR1 gene that may be involved in mRNA trafficking from the nucleus to the cytoplasm and is implicated in Fragile X Syndrome and Premature Ovarian Failure. This evidence concerns the gene FMR1 and primary ovarian failure.