By analyzing molecular signaling pathways, we identified seven cancer-specific pathways; the focal adhesion kinase (FAK)/PI3K-Akt signaling pathway, JAK-STAT pathway, Notch signaling pathway, receptor tyrosine kinase/PDGF signaling pathway, TGF-β signaling pathway, VEGFA signaling pathway, and Wnt signaling pathway are significantly altered in the S:E fusion-positive group. This evidence concerns the gene PTK2 and cancer.