From another point of view, far from the prevailing line of thought that cholinergic theory, the Aβ cascade hypothesis or the abnormally excessive phosphorylated Tau protein are the sole main aspects of the pathogenesis of AD, another opinion has been expressed by many scientists who have focused on what they suspect to be another etiology, or an alternative theory, that depends more on the central factors that may underpin the pathogenesis of AD and other dementias. The gene discussed is MAPT; the disease is Alzheimer disease.