Thus, immunosenescence manifests as an increased vulnerability to foreign pathogens, altered naïve T cell/memory cell ratio, a decrease in the immune responses due to a decline in lymphocyte proliferation, especially in aging, increased blood levels of IgG and IgA, poor responses to vaccinations, the excessive onset and progression of autoimmune diseases, the steady state of low-grade inflammation and then onset of tumors [227,228,229,230]. This evidence concerns the gene CD79A and autoimmune disease.