The discovery of AKT dates back to the 1970s, when an oncogene sequence, named AKT8, was identified in murine leukemia viruses, and two homologous oncogenes of AKT8, named AKT1 and AKT2 (also known as PKKB αand PKKB β, respectively), were subsequently identified in human chromosomes (Pastorino et al., 2005). The gene discussed is AKT1; the disease is leukemia.