IL10 and leishmaniasis: In fact, B cell activity is often described as detrimental in the context of leishmaniasis: IgG-coated L. major amastigotes could be internalized more efficiently by murine macrophages, subsequently inducing IL-10 production (Kane and Mosser, 2001) which has been described as detrimental for, among other effects, supposedly aiding the shift from a predominantly Th1 profile to a predominantly Th2 (Ghalib et al., 1995; Revaz-Breton et al., 2010).