TNFSF13B and Splenomegaly: The correlation between B cells and a poor prognosis in leishmaniasis was also evidenced by the work of Omachi et al., demonstrating that animals deficient in B cell activating factor (BAFF) can suppress the splenomegaly characteristic of the disease in the experimental model of VL with L. donovani, but not hepatomegaly (Omachi et al., 2017).