The experimental results showed that the mRNA expression levels of Il-1β, IFN-γ, Cd163, and Iba1 in the brain tissue of AD mice in the Zun-Pre group were upregulated compared with those in the model group, which indicated that the number of microglia in the brain tissue of the mice in this group was upregulated. The gene discussed is AIF1; the disease is Alzheimer disease.