Studies have shown that lncRNA NEAT1 carried by EVs in sepsis was associated with the aggravation of sepsis-related encephalopathy (Wei et al., 2022), lncRNA TUG1 was involved in promoting macrophage M2 polarization (Ma et al., 2021), and lncRNA-p21 can inhibit LPS-induced lung cells injury, lncRNA IGF2-AS promoted endothelial progenitor cell pyroptosis (Sui et al., 2021a; Liang et al., 2022). This evidence concerns the gene IGF2 and Sepsis.