FAS and Hepatic fibrosis: LPS can cause disorders to the immune system within the liver via “gut-liver” axis and mediate the inflammatory cascade, up-regulate Fas antigen expression in liver cells, activate Kupffer cells and hepatic stellate cells, thereby accelerating liver apoptosis, promoting the formation of the extracellular matrix, leading to liver injury and progression of liver fibrosis (Muschen et al., 1998; Henao-Mejia et al., 2012; Kumar et al., 2017; Castillo-Dela Cruz et al., 2019; Hu et al., 2020; Hu et al., 2021; Forlano et al., 2022).