TLR4 and liver cancer: This complex then enters the liver through the circulation of the portal vein, triggering a cascade of intracellular signals in liver through TLR4, which eventually leads to exacerbated liver fibrosis (Seki et al., 2007), cirrhosis (Milosevic et al., 2019; Wang et al., 2022) and even liver cancer (Meng et al., 2018).