Wang et al. (2021) found that FDX1 was involved in mitochondrial steroid metabolism, and played a role in the development of polycystic ovary syndrome. FDX1 facilitates copper-dependent cell death; an analysis of FDX1 action shed light on how cells respond to proteotoxic stress (Tsvetkov et al., 2019). FDX1 increases ATP production and plays key roles in glucose metabolism, fatty acid oxidation, and amino acid metabolism in lung adenocarcinoma cells (Zhang et al., 2021). This evidence concerns the gene FDX1 and lung adenocarcinoma.