HGF and neoplasm: The relationship between tumors and inflammatory responses can be reflected by the levels of specific substances in blood or tumor specimens (Allen et al., 2007), including interleukin-6, IL-8, growth-associated oncogene -1, vascular endothelial growth factor, hepatocyte growth factor, and cytokines, and elevated levels of growth factors associated with tumor progression and recurrence (Karki et al., 2017).