The inflammatory response is tightly involved in the progression of a stroke, under stroke conditions, the body is in a pro-inflammatory state, and the C-reactive protein (CRP), IL-1β, IL-6, and tumor necrosis factor-α (TNF-α) were significantly increased following stroke (25, 26), and these inflammatory factors were all reported to be associated with the development of AKI (27, 28). This evidence concerns the gene IL6 and stroke disorder.