44 patients (3.2%) died from CeVD.Overall CeVD SMR: 2.06CeVD mortality was significantly elevated in patients under 35 years old.CeVD mortality increased with longer duration of acromegaly, while cardiovascular disease mortality did not.CeVD mortality was not affected by post-treatment GH levels, while cardiovascular disease mortality was.CeVD mortality was higher in younger populations, while cardiovascular disease mortality was not. The gene discussed is GH1; the disease is cardiovascular disorder.