When examining by tumor type, the highest SIR was uncovered among patients with ACTH and TSH-secreting adenomas (SIR 3.75), followed by NFPAs without hypopituitarism (3.12), NFPAs with hypopituitarism (3.1), prolactinomas (2.9), and lastly GH subtypes (1.8). The gene discussed is POMC; the disease is hypopituitarism.