Comparing novel markers of metabolic complications and cardiovascular risk factors revealed that fetuin-A levels were higher among obese non-diabetic children, 667.18 ± 363.12 vs. 388.87 ± 253.75 [μg/ml] (p = 0.01); E-selectin, 815.87 ± 751.92 vs. 582.01 ± 645.75 [ng/ml], and OPG levels, 0.10 ± 0.04 vs. 0.10 ± 0.03 [ng/ml], were similar in both groups with obesity. The gene discussed is SELE; the disease is obesity due to melanocortin 4 receptor deficiency.