In cancers, DHX9 has been widely reported to promote proliferation, invasion, and metastasis of cancer cells and significantly correlated with poor prognosis, including prostate cancer (7), non-small-cell lung cancer (NSCLC) (8), and hepatocellular carcinoma (HCC) (9), which may function as epigenetic regulation of gene expression program (7, 10) and influence in mRNA stability (11). This evidence concerns the gene DHX9 and hepatocellular carcinoma.