DHX9, as an NTP-dependent helicase protein, plays a vital role in varieties of cellular processes, and aberrant DHX9 expression participates in multiple human diseases (14, 15) including various cancers, e.g. colorectal cancer (CRC) (16), hepatocellular carcinoma (9), and prostate cancer (7). The gene discussed is DHX9; the disease is hepatocellular carcinoma.