DHX9 and Familial prostate cancer: In cancers, DHX9 has been widely reported to promote proliferation, invasion, and metastasis of cancer cells and significantly correlated with poor prognosis, including prostate cancer (7), non-small-cell lung cancer (NSCLC) (8), and hepatocellular carcinoma (HCC) (9), which may function as epigenetic regulation of gene expression program (7, 10) and influence in mRNA stability (11).