By interacting with the transcriptome data from The Cancer Genome Atlas (TCGA), we found that the specifically bound transcripts of EZH2 and JARID2 in HepG2 cells were higher expressed in HCC samples by analyzing the RNA-binding profiling from CLIP-seq data, showing the H3K27-independent role of EZH2 and JARID2. Here, JARID2 is linked to hepatocellular carcinoma.