Interestingly, B cell malignancies produce IL-10 and TGF-β (Gupta et al., 2012; Huai et al., 2021), while non-Hodgkin’s lymphoma cells upregulate CD70 expression on T cells through TGF-β (Yang et al., 2014). The gene discussed is TGFB1; the disease is non-Hodgkin lymphoma.