USP8 and cancer: Since survival pathways activated by RTKs have been shown to be frequently de-regulated in cancer cells, particularly in platinum drug-resistant cells (Cossa et al., 2014; Corno et al., 2017), the aim of this study was to investigate the possible contribution of USP8 to drug resistance of ovarian carcinoma cells with particular reference to platinum-resistant preclinical models, using a RNA interference-based approach.