These include the RBR E3 ligase Parkin, which is a major source of recessive mutations that give rise to Parkinson’s disease (Fiesel et al., 2014) and the RING E3 ligase CHIP/STUB1, which is mutated in several subcategories of hereditary spinocerebellar ataxia (Heimdal et al., 2014; Kanack et al., 2018). Here, STUB1 is linked to Parkinson disease.