Our experimental work revealed that BNIP3, SLC38A5, CKMT2, CXCL11, SLC5A3, and S100A3 were expressed at higher levels, whereas PGM1 was expressed at lower levels in osteosarcoma cells compared with normal osteoblasts, highlighting the significance of the above genes in the occurrence and development of osteosarcoma. This evidence concerns the gene CXCL11 and osteosarcoma.