Functionally, EphA3 overexpression strengthened the proliferation and migration of A375 and A875 cells; on the contrary, miR-3666 mimic weakened two malignant behaviors of melanoma cells; more importantly, the promotion of EphA3 overexpression on melanoma cell growth was blockaded by miR-3666 mimic (Figure 5b and c). The gene discussed is EPHA3; the disease is melanoma.