PAI-1, a promising prognostic factor involving in selective degradation of extracellular matrix components (Andreasen et al., 1997; Fredstorp-Lidebring et al., 2001), has been found to be associated with neovascularization, invasion, and migration in breast (Schmitt et al., 2010), prostate (Almasi et al., 2011), colorectal (Markl et al., 2017), ovarian (Zhang et al., 2013), and endometrial cancers (Tecimer et al., 2001). Here, SERPINE1 is linked to endometrial cancer.