Found to be anti-obesity via reduction in COX2, NF-kB, TNF-α, inflammation, insulin resistance and oxidative stress. It was also found to be anti-inflammatory in later models via the downregulation of C- JNK, ERK-1/2, P38, IL-1β like proteins. The gene discussed is MAPK3; the disease is obesity due to melanocortin 4 receptor deficiency.