SSI-4 was already used in a preclinical model of hepatocellular carcinoma (Ma et al., 2017), while the betulinic acid, as well as MF-438 were both employed in preclinical models of CRC and lung cancers, respectively (Potze et al., 2016; Pisanu et al., 2017). This evidence concerns the gene SOCS6 and lung carcinoma.