In alignment with these discoveries, we found that depression-related behaviors induced by HFD were more obvious in WT-HFD mice versus WT-chow diet mice both in TST and FST (WT-Chow 62.27 ± 14.26 vs. WT-HFD 159.8 ± 20.61, p < 0.0001; C/EBPβ+/−-Chow 63.78 ± 7.404 vs. C/EBPβ+/−-HFD 74.31 ± 8.298, p > 0.05; Figure 3H; WT-Chow 74.19 ± 7.996 vs. WT-HFD 151.2 ± 15.47, p < 0.0001; C/EBPβ+/−-Chow 67.35 ± 7.515 vs. C/EBPβ+/−-HFD 75.64 ± 7.691, p > 0.05; Figure 3I). The gene discussed is CEBPB; the disease is depressive symptom measurement.