Consistent with these molecular level findings, the TST and FST results showed that HFD-induced depression-like behaviors were more remarkable in C/EBPβ transgenic HFD mice than that in the corresponding chow diet mice and in both wild-type groups (WT-Chow 76.5 ± 7.06 vs. WT-HFD 84.53 ± 4.825, p > 0.05; C/EBPβ Tg-Chow 94.9 ± 10.62 vs. C/EBPβ Tg-HFD 143.9 ± 14.5, p = 0.008; Figure 4H; WT-Chow 76.81 ± 6.882 vs. WT-HFD 63.41 ± 6.776, p > 0.05; C/EBPβ Tg-Chow 82.77 ± 8.465 vs. C/EBPβ Tg-HFD 135.1 ± 15.08, p = 0.0038; Figure 4I). This evidence concerns the gene CEBPB and depressive disorder.