To confirm that BDNF and its major ligand-specific receptor TrkB mediates induces C/EBPβ-induced depression, we treated WT and Thy1-C/EBPβ Tg male mice with 7,8-DHF during the last 4 weeks of a 12-week HFD course a (Figure 8A). The gene discussed is BDNF; the disease is major depressive disorder.