Overexpression of HK2 not only accelerates glucose uptake, but also activates multiple pathways required for glucose influx into Kras-driven PC growth, including the pentose phosphate pathway, serine synthesis pathway, and hexosamine biosynthesis pathway, which protomes the proliferation, invasion, and metastasis of PC (46, 47). The gene discussed is KRAS; the disease is pachyonychia congenita.