CD8A and neoplasm: Reduction of hyaluronan and collagen production in the TME by inhibition of the rate-limiting enzyme glutamine-fructosamidyltransferase 1 (GFAT1) of HBP leads to extensive remodeling of the ECM and increased levels of CD8(+) T infiltration, while enhancing PD1 treatment responses, eventually resulting in tumour regression (249, 250).