PKM and neoplasm: The continuous secretion of recruitment factors [such as G-CSF, Bv8, C-X-C motif ligand 1 (CXCL1) and CCL2] by tumour cells into the microenvironment enhances neutrophil infiltration and stimulation of the microenvironment enhances the activities of lactate dehydrogenase and PKM2 in neutrophils, which in turn uses anaerobic glycolysis to generate energy.