Interleukin 1 receptor-associated kinase 2 (IRAK2), which is highly expressed in PC, promotes the expressions of GLUT1, phosphoglucose isomerase (GPI1), and PDK1 by activating the immune-related pathway (NF-κB), thereby increasing glucose consumption and lactate production in cancer cells, providing bioenergetic and metabolic requirements for their survival and proliferation (251). Here, IRAK2 is linked to cancer.