At this time, the glycolytic rate of tumour cells in the hypoxic area increases, producing significant lactate, which is then converted into pyruvate by the oxidation of MCT1 and LDHB oxidation and accelerates oxidative phosphorylation of tumour cells in the oxygen-containing region, which realizes the metabolic symbiosis of hypoxic and oxygen-containing cancer cells. Here, LDHB is linked to neoplasm.