C5AR1 and breast cancer: For instance, the newly identified C5aR1 subset, whose phenotypic markers include CD66B, CD15, and C5aR1, can be transferred via extracellular signal-regulated kinase 1/2 (ERK1/2)-WTAPENO1 signaling to promote the glycolytic capacity of breast cancer, including the rate of glucose uptake and lactate production.