HK2 and neoplasm: As an important regulator of Wnt transduction in the canonical signaling pathway in tumours, Dickkopf-related protein 3 (DKK3) negatively regulates aerobic glycolysis [HK2, HIF-1α, GLUT-1, LDHA and 3-phosphoinositide-dependent protein kinase-1 (PDK-1)] in BxPC-3 cells.