The ApoE genotypes present differential effects on lipid-binding ability, amyloid-β (A-β) aggregation and clearance, and the susceptibility of the blood-brain barrier (Liu et al., 2013), and are linked to a neurodegenerative process (Mahley, 2016), including AD, vascular dementia, and mixed dementia (Liu et al., 2012). This evidence concerns the gene APOE and Alzheimer disease.