Furthermore, using coated‐beads aggregation assays, data supporting the heterophilic theory showed that a pathogenic pemphigus mAb blocked heterophilic interaction of Dsg/Dsc without the involvement of intracellular signaling or other cellular processes, suggesting steric hindrance by the autoantibodies as the primary pathogenic mechanism in pemphigus.28, 29. This evidence concerns the gene DSG1 and pemphigus.