DSC3 and pemphigus: Furthermore, using coated‐beads aggregation assays, data supporting the heterophilic theory showed that a pathogenic pemphigus mAb blocked heterophilic interaction of Dsg/Dsc without the involvement of intracellular signaling or other cellular processes, suggesting steric hindrance by the autoantibodies as the primary pathogenic mechanism in pemphigus.28, 29