Previous studies have discovered genetic mutations in IPNB and IPMN through next-generation sequencing (NGS) method, such as GNAS, KRAS, TP53, STK11, CTNNB1, RNF43, APC, SMAD4, EGFR, etc. [4]. The gene discussed is EGFR; the disease is pancreatic intraductal papillary-mucinous neoplasm.