To explore the influences of IL-3 and sTREM2 on AD pathology, two mediation pathway analyses were used including: (1) CSF Aβ42 → CSF IL-3 → CSF sTREM2; (2) CSF IL-3 → CSF sTREM2 → CSF p-tau/t-tau. The gene discussed is MAPT; the disease is Alzheimer disease.