Considering mitochondrial function in inflammasome activation [111], and VDAC1 being the mitochondria governor, VBIT-4 by interacting with VDAC1, inhibits apoptosis, reduces ROS production, cellular Ca2+ [41] and inflammatory response, and restores cell metabolism – all these lead to alleviated AD symptoms. This evidence concerns the gene VDAC1 and Alzheimer disease.