A link between VDAC1 expression levels and AD has also recently been demonstrated in double mutant (VDAC1 +/−/TAU) transgenic mice, showing that a partial reduction in VDAC1 levels rescues motor coordination and learning and spatial memory, and enhances mitophagy, autophagy, and synaptic activities [107]. The gene discussed is VDAC1; the disease is Alzheimer disease.