The AIM2 inflammasome is activated in ischemic mouse brains [65], and NLRC4 and NLRP3 activate an LPS-induced inflammasome in astrogliosis and microgliosis [66], while NLRP6 and NLRP3 inflammasomes negatively regulate NAFLD/NASH progression [67]. Here, AIM2 is linked to metabolic dysfunction-associated steatotic liver disease.