On the one hand, lactic acid can provide fuel for the oxidative metabolism of oxidized tumor cells [4, 5], and up-regulate vascular endothelial growth factor (VEGF) in tumor cells and IL-8 in endothelial cells through a series of signaling pathways [6], synergically acting on lactic acid-induced tumor angiogenesis [7], thus facilitating tumor invasion and metastasis [8, 9]. The gene discussed is VEGFA; the disease is neoplasm.