The levels of NT-proBNP, HMGB1 and ACTA in the severe group were higher than those in the moderate group, while the 25-(OH) D and electrolyte levels were lower than those in the moderate group, with statistically significant differences (P <0.001), The incidence of hyperglycemia in severe group (16 cases) was the lowest, significantly lower than that in moderate group (17 cases) and mild group (22 cases), and the difference was statistically significant (all P<0.05), as shown in Table 3. Here, HMGB1 is linked to Hyperglycemia.