The levels of NT-proBNP, HMGB1, ACTA, incidence of hypoglycemia and hyperglycemia in the study group were higher than that in the control group, while levels of 25-(OH) D and and electrolyte levels were lower than that in the control group, the differences were statistically significant (all P < 0.001) (Table 2). This evidence concerns the gene NPPB and Hypoglycemia.