Yue et al. confirmed that BUB1B could be a key target for promoting NPC metastasis through bioinformatics tools, but only two GEO data sets were used in the study with a small sample size [12].Further, no comprehensive analysis has been conducted to illustrate the clinical role of BUB1B expression and to explore its underlying mechanism in NPC by far. The gene discussed is BUB1B; the disease is nasopharyngeal carcinoma.