Here, we searched the data sets from different high throughput sources, including Gene Expression Omnibus (GEO), Sequence Read Archive (SRA), ArrayExpress, Oncomine, The Cancer Genome Atlas (TCGA) and the literatures that contained the expression pattern of BUB1B in NPC, and conducted a systematic investigation into the collected information. Here, BUB1B is linked to nasopharyngeal carcinoma.