AFP and neoplasm: For instance, Zhou Q et al. reported alkaline phosphatase (> 125U/L), alpha-fetoprotein (within 20–400 or ≥ 400 ng/mL), protein induced by vitamin K absence-II (within 40–400 or ≥ 400mAU/mL), tumor diameter, multiple tumors, pseudo-capsule, the infiltrative border with an irregular shape, and intratumor hemorrhage were independent risk factors of MVI [16].