TLR4 and myocardial infarction: Zhao et al. reported that BM-MSC-derived EVs (BM-MSC-EVs) maintain anti-inflammatory macrophage phenotype polarity in a mouse MI model via miRNA-182 delivery, which has important effects on cardiac repair, inhibition of toll-like receptor 4 (TLR4) in recipient cells, and immune regulatory properties [96].