Extending our recent work examining candidate AD treatments targeting the JAK/STAT cytokine signaling pathway [3, 9], we now demonstrate that HCQ lowers the incidence of ADRD compared to MTX in older individuals, rescues impaired hippocampal synaptic plasticity in APP/PS1 mice and corrects multiple molecular abnormalities underlying AD. The gene discussed is SOAT1; the disease is Alzheimer disease.