Furthermore, the GO term microglial cell activation involved in immune response (GO:0002282) was significantly disrupted in temporal cortex with respect to PRS and it comprises TYROBP, TREM2, GRN and IL33. TYROBP was significantly up-regulated in response to higher PRS in temporal cortex and has been shown as a strategic and causal regulator in several microglial activation signalling cascades and the complement pathway in late onset AD [40]. Here, GRN is linked to Alzheimer disease.