The top ranked 15 genes in the temporal cortex also found in AD GWAS hits were HAVCR2, MS4A6A, INPP5D, ECHDC3, SPI1, ADAMTS4, ADAMTS1, CR1, IL34, PICALM, HLA-DRB1, CD33, APH1B, FERMT2, and PLCG2, although only HAVCR2 and MS4A6A (p = 1.61 × 10−02, beta = 0.21 and p = 3.72 × 10−02; beta = 0.29), passed FDR correction. The gene discussed is PICALM; the disease is Alzheimer disease.