When we conducted GSEA using RNA sequence data from cells derived from patients with WS, the expression of a set of nuclease activity genes tended to be lower than that in normal fibroblasts (TIG-3 or NF; Supplementary Fig. 7a, b and Supplementary Data 3), as similarly observed in senescent cells47,48 (Fig. 1a). This evidence concerns the gene NFASC and Werner syndrome.