In comparison to our previous studies in A7 melanoma cells which contain high levels of nuclear FLNA [15, 29], the FLNA content in HuH7 cells was equally distributed (Fig. S2B) and therefore an interaction between MRTF-A and FLNA detectable both in the cytoplasm and nucleus in HuH7 cells expressing control siRNA. Here, MRTFA is linked to melanoma.