TPM1 and ischemia reperfusion injury: A proteomic analysis revealed that cardiac ischemia-reperfusion injury causes Kcro of proteins associated with cardiomyocyte contractility, resulting in the disruption of cardiomyocyte mitochondrial, sarcomere architecture, and gap junction, as well as the induction of cardiomyocyte apoptosis.203 The pathological role of Kcro modification on cytoskeletal protein tropomyosin alpha-1 chain (TPM1) and metabolic enzyme IDH3a were further investigated.