Bowers et al. and shrimp et al. obtained a pyrazolone small molecule compound (C646) through virtual screening, which has been demonstrated to inhibit tumor proliferation, promote tumor apoptosis, alter glucose metabolism, reduce tumor drug resistance and induce tumor immune response in different kinds of cancers.336–343 For example, in our study, C646 was confirmed to inhibit the K240 of TRIB3 and promote CD8+ T-cell recruitment in CRC tissues. Here, TRIB3 is linked to neoplasm.