OTUD3 and COVID-19: Acetylation of cGAS by KAT5 in its N-terminal domain promotes its DNA-binding ability, increasing the transcription of downstream antiviral genes.150 In addition to the DNA virus infection, acetylation of OTU deubiquitinase 3 (OTUD3) has been verified to be critical to the RNA virus infection.151 Since 2019, SARS-CoV-2 has caused an ongoing pandemic of coronavirus disease 2019 (COVID-19) worldwide.152 Protein acetylation has also been studied in this severe acute respiratory syndrome.