The stabilized DOT1L catalyzes the H3K79 methylation of genes involved in EMT, including Snail and ZEB1, thus promoting CRC metastasis.115 Krüppel-like Factor 5 (KLF5) is a key transcriptional factor in regulating cell proliferation, apoptosis, tumor cell stemness traits and EMT.116,117 Acetylation of KLF5 has been reported to play opposite roles in the progression of prostate cancer and breast cancer via regulating its transcriptional activity or protein stability. Here, KLF5 is linked to colorectal carcinoma.