IFN-γ signaling plays a critical role in antitumor responses, as it activates the Janus kinase (JAK) signal transducer and activator of transcription 1 (STAT1) pathway to induce the expression of classical interferon-stimulated genes that have key immune effector functions.299 recent work found that C122 palmitoylation in IFN-γ receptor 1 (IFNGR1) acts as a sorting signal for IFNGR1 lysosomal degradation mediated by AP3D1 in CRC. The gene discussed is STAT1; the disease is colorectal carcinoma.