They explained that EGFR palmitoylation appears to be necessary for PI3K-AKT-Myc signaling in lung cancer, revealing that ZDHHC20 inhibition represents a therapeutic vulnerability in the PI3K-AKT pathway.291 Melanocortin-1 receptor (MC1R) is a key protein in determining hair and skin pigments. Here, ZDHHC20 is linked to lung cancer.