DOT1L and cancer: This results in increased acetyl-CoA and SMAD2 acetylation, which finally upregulates its transcriptional activity and promotes EMT programs in breast tumor cells.112 DOT1L is a histone methyltransferase that regulates various genes involved in cancer onset and metastasis.113,114 CBP promotes DOT1L acetylation at K358 and enhances its stability by preventing the binding of RNF8 and DOT1L.