Glyceronephosphate O-acyltransferase (GNPAT) is critical for the synthesis of fatty acids, which are dysregulated in hepatocellular carcinoma (HCC).98 The acetyltransferase ACAT1 is upregulated in response to extra palmitic acid (PA) and acetylates GNPAT at K128, which represses tripartite motif-containing 21 (TRIM21)-mediated ubiquitination and degradation of GNPAT. The gene discussed is ACAT1; the disease is hepatocellular carcinoma.