In addition to its glycolytic function, there is growing evidence to show that ENO1 is an oncogene in CRC tissues.205,206 It was reported that CBP mediates the crotonylation of ENO1 at K420 to promote tumor growth, migration, and invasion of CRC cells in vitro by enhancing ENO1 enzymatic activity and regulating the expression of tumor-associated genes.207. This evidence concerns the gene CREBBP and neoplasm.