TGFB1 and obesity due to melanocortin 4 receptor deficiency: Obesity-associated high protein expression of leptin and TGF-β has been demonstrated to upregulate SMAD2 acetylation by inactivating ACC1 and promoting breast cancer metastasis.314 The donors of myristoylation and palmitoylation, myristic acid, and palmitic acid mainly exist in natural vegetable oil.