In a study of tumor and diet, researchers found that β-OHB produced by ketogenic diet with low carbohydrate and high fat inhibits CRC development.215 On the contrary, β-OHB treatment induced Kbhb of p53 at K120, K319, and K370 by CBP/p300 to attenuate the cell growth arrest and apoptosis-inducing functions of p53.216 Mechanistically, p53 kbhb results in reduced p53 acetylation and inhibits the expression of p21 and PUMA, two downstream target genes of p53. This evidence concerns the gene EP300 and colorectal carcinoma.