CD274 and cancer: Programmed cell death 1 ligand 1 (PD-L1), which is expressed on cancer cells, binds to the receptor PD-1 on T cells to prevent their proliferation and reduce the anti-tumor immune response, resulting in T-cell exhaustion.125–127 Researchers found that the acetylation of PD-L1 or related transcription factors could regulate its subcellular localization.