This results in increased acetyl-CoA and SMAD2 acetylation, which finally upregulates its transcriptional activity and promotes EMT programs in breast tumor cells.112 DOT1L is a histone methyltransferase that regulates various genes involved in cancer onset and metastasis.113,114 CBP promotes DOT1L acetylation at K358 and enhances its stability by preventing the binding of RNF8 and DOT1L. Here, DOT1L is linked to breast neoplasm.