In the study of hepatic steatosis, Guo et al. found that the subunit of nuclear factor-κb (NF-κB)—p50 stabilizes HDAC1 to downregulate SREBP1c Ksuc, which increases SREBP1c stability and aggravate hepatic steatosis.172 The different influence of Ksuc on protein stability in S100A10 and SREBP1c indicate an uncovered complex regulatory mechanism of Ksuc. Here, HDAC1 is linked to fatty liver disease.