CREBBP and neoplasm: In a study of tumor and diet, researchers found that β-OHB produced by ketogenic diet with low carbohydrate and high fat inhibits CRC development.215 On the contrary, β-OHB treatment induced Kbhb of p53 at K120, K319, and K370 by CBP/p300 to attenuate the cell growth arrest and apoptosis-inducing functions of p53.216 Mechanistically, p53 kbhb results in reduced p53 acetylation and inhibits the expression of p21 and PUMA, two downstream target genes of p53.