CD274 and colorectal carcinoma: They found that the palmitoylation of PD-L1 increases its binding with PM and inhibits its ubiquitination-mediated lysosomal degradation, while the PAT is ZDHHC3 but not ZDHHC9 in CRC.297 The same group further illuminated the regulatory role of palmitoylation on PD-1 stability in tumor cells.