PCAF-mediated acetylation of LDHB at K82 was found to significantly decrease its enzymatic activity and impair hepatic lactate clearance, resulting in lactate accumulation, which exacerbates lipid deposition and inflammatory responses by activating histone hyperacetylation in high-fat diet (HFD)-induced NAFLD.148 All of the evidence suggests the importance and complex of Kace in regulating metabolic diseases and provides potential therapeutic targets from the view of protein PTMs. Here, LDHB is linked to metabolic dysfunction-associated steatotic liver disease.