This modification attenuates the association of TRIB3 with the E3 ligase SIAH1 and inhibits its ubiquitination and degradation.138 On one hand, aberrant highly expressed TRIB3 enhances the stemness of cancer cell by activating the Wnt/β-catenin signaling pathway.102 On the other hand, TRIB3 represses the STAT1-CXCL10 axis and reduces CD8+ T-cell infiltration, resulting in the immune evasion of CRCs. The gene discussed is TRIB3; the disease is cancer.