CLDN3 and cancer: The membrane protein claudin-3 (CLDN3) is critical for the formation and maintenance of tight junctions and is highly expressed in numerous cancers.286 ZDHHC12 mediates CLDN3 S-palmitoylation on three juxtamembrane cysteine residues (C181, C182, and C184), which contribute to its accurate localization in plasma membranes and protein stabilization, promoting ovarian cancer tumorigenesis.