While, in the NAFLD, SIRT2 prevents liver steatosis and metabolic disorders by deacetylating and stabilizing hepatocyte nuclear factor 4α (HNF4α) at K458.147 In both of the two studies, Kace works on the transcription factors via regulating their protein stability but not transcriptional activity, providing a novel regulatory mechanism of acetylation on transcription factors. Here, SIRT2 is linked to metabolic dysfunction-associated steatotic liver disease.