The membrane protein claudin-3 (CLDN3) is critical for the formation and maintenance of tight junctions and is highly expressed in numerous cancers.286 ZDHHC12 mediates CLDN3 S-palmitoylation on three juxtamembrane cysteine residues (C181, C182, and C184), which contribute to its accurate localization in plasma membranes and protein stabilization, promoting ovarian cancer tumorigenesis. The gene discussed is ZDHHC12; the disease is cancer.