LC–MS/MS analysis have suggested a tight connection between succinylome and diabetes/hepatic steatosis.169,170 Ksuc of optineurin (OPTN), the autophagy receptor, and sterol-regulatory element binding protein 1c (SREBP1c), the key transcription factor in de novo lipogenesis, have been studied in diabetic retinopathy (DR) and hepatic steatosis respectively in depth. The gene discussed is SREBF1; the disease is fatty liver disease.