We further explored the expression of DYRK2 in different colorectal cell lines and 5-FU resistant cells (5-FUR), and observed low levels of DYRK2 expression in CRC 5-FUR lines (LoVo 5-FUR, HCT116 5-FUR, SW480 5-FUR) as compared to parent cells (LoVo, HCT116, SW480) at both the protein and mRNA levels (Fig. 2A). This evidence concerns the gene DYRK2 and colorectal carcinoma.